| Unlockable: | How to Unlock: |
| Arctic Explorer (20 Pts) | Complete Military Base Level |
| Cold War Relic (20 Pts) | Complete Red Ghost Level |
| Doomed (30 Pts) | Defeat Dr. Doom |
| Elemental Master (20 Pts) | Defeat Terrax |
| Hero (160 Pts) | Complete the game in regular mode |
| Human Torch (110 Pts) | Upgrade all of the Human Torch's Powers |
| Invisible Woman (110 Pts) | Upgrade all of the Invisible Woman's Powers |
| Mr. Fantastic (110 Pts) | Upgrade all of Mr. Fantastic's Powers |
| Rock Crusher (20 Pts) | Complete Himalayas Level |
| Shanghai Surprise (20 Pts) | Complete Shanghai Level |
| Skrull Slayer (20 Pts) | Complete Skrull Lair Level |
| Skrull's Demise (20 Pts) | Defeat Super Skrull |
| Superhero (200 Pts) | Complete the game in Fantastic mode |
| Thing (110 Pts) | Upgrade all of The Thing's Powers |
| Wedding Crasher (20 Pts) | Complete New York Level |
